李琦，副教授，硕士研究生导师。2019年毕业于中国科学院上海生科院植物生理生态研究所（现为中国科学院分子植物科学卓越创新中心），获博士研究生学位。2015-2018年访学英国诺丁汉大学2次。四川师范大学2019年引进人才。目前主要研究方向为微生物遗传与基因组编辑、川酒酿造微生物资源挖掘与应用、微生物合成生物学等。以第一作者或通讯作者发表论文二十余余篇。主持国家自然科学基金1项、主持四川省自然科学基金2项、主持中国科学院合成生物学重点实验室开放课题1项、主持四川省固态酿造重点实验室开放课题1项、主持四川师范大学引进人才科研启动项目1项、主持横向项目5项。

     Qi Li, Associate Professor. She graduated from the Institute of Plant Physiology and Ecology of the Chinese Academy of Sciences in 2019 (now the CAS Center for Excellence in Molecular Plant Science) and received the PhD degree. She visited the University of Nottingham (UK) twice from 2015 to 2018. She joined the College of Life Sciences at Sichuan Normal University in 2019. Her current research focuses mainly on microbial genetics and genome editing, mining and application of microbial resources in Baijiu brewing, and synthetic biology. She has published over 20 papers as the first author or corresponding author. She has presided over a project funded by the National Natural Science Foundation of China, two projects funded by Natural Science Foundation of Sichuan Province, one project funded by the Key Laboratory of Synthetic Biology of the Chinese Academy of Sciences, one project funded by the Key Laboratory of Solid Fermentation of Sichuan Province, one project funded by Sichuan Normal University, and 5 projects in collaborated with companies.

近五年发表的主要论文

Main Papers Published In The Past Five Years

1. Sun M, Gao J, Tang H, Zhou L, Wang H, Song C, Tian Y, Li Q. D-CAPS: An efficient CRISPR-Cas9-based phage defense system for E. coli. Acta Biochimica et Biophysica Sinica. (Accepted)

2. Sun MJ, Gao J, Tang HJ, Wu T, Zhang SY, Zuo Y, Ma QQ, Li Q. Increasing the CRISPR-Cas9-mediated gene editing efficiency in T7 phage by reducing the escape rate based on the insight of survival mechanism. Acta Biochimica et Biophysica Sinica. 2024, 56(6):937-944

3. Li Q, Sun M, Lv L, Zuo Y, Zhang S, Zhang Y, Yang S. Improving the editing efficiency of CRISPR-Cas9 by reducing the generation of escapers based on the surviving mechanism. ACS Synthetic Biology. 2023, 12(3): 672-680.

4. Li Q, Wang YW, Lv L, Dong L, Zhao C, Zhang FJ, Li ZH. Characterizing of organic acid, flavor components and microbial community of low-salt fermented red pepper sauce and analyzing the metabolic pathway of major flavor components. Food Bioscience. 2023, 56(103423).

5. Gao Y, Zhang S, Chen H, Chen J, Zuo Y, Li Q. Screening and mutagenesis of amylase-producing strains from pit mud of strong-flavor Baijiu. China Brewing. 2023. 42(06).

6. Huang Q, Su Y, Zuo Y, Li Q. Directional domestication of Saccharomyces cerevisiae tolerant to high concentration ethanol and its application in mulberry wine brewing. Food and Fermentation Industries. 2023. 49(12).

7. Li Q, Sun B, Chen J, Zhang Y, Jiang Y, Yang S. A modified pCas/pTargetF system for CRISPR-Cas9-assisted genome editing in Escherichia coli. Acta Biochimica et Biophysica Sinica. 2021, 53(5): 620-627

8. Jia YL, Geng SS, Du F, Xu YS, Wang LR, Sun XM, Wang QZ, Li Q. Progress ofmetabolic engineering for the production of eicosapentaenoic acid. Critical Reviews In Biotechnology. 2021, 42(6):838-855

9. Li Q, Zhang JZ, Yang JJ, Jiang Y, Yang S. Recent progress on n-butanol production by lactic acid bacteria. World Journal of Microbiology & Biotechnology. 2021, 37(12).

10. Li Q, Wu M, Wen Z, Jiang Y, Wang X, Zhao Y, Liu J, Yang J, Jiang Y, Yang S. Optimization of n-butanol synthesis in Lactobacillus brevis via the functional expression of thl, hbd, crt and ter. Journal of Industrial Microbiology & Biotechnology, 2020, 47(12): 1099-1108.

11. Li Q, Seys FM, Minton NP, Yang J, Jiang Y, Jiang W, Yang S. CRISPR-Cas9(D10A) nickase-assisted base editing in the solvent producer Clostridium beijerinckii. Biotechnology and Bioengineering. 2019, 116(6): 1475-1483.

12. Li Q, Wu M, Guo Q, Shao Y, Yang J, Yang S, Jiang Y. Progress in bacterial genome editing rechnology. Chinese Bulletin of Life Sciences. 2019, 31(5): 473-492.

联系方式：

Contact Information

E-mail: liqi@sicnu.edu.cn

Tel: 15802866175

编辑：生命科学学院   审核：生命科学学院   终审：生命科学学院