朱博，博士，教授，四川省“天府峨眉计划”入选者，四川省特聘专家，四川省学术技术带头人后备人选，四川师范大学“狮山学者”，四川师范大学植物功能基因组及生物信息学研究中心负责人。在Plant cell，PNAS等国际权威期刊发表文章近20篇，曾获“吉林省科技进步一等奖”、成都青年五四奖章、成都市最美科技工作者提名奖。主持国家级、省部级项目10项；目前主要从事青稞功能基因组学及进化方面的研究。
课题组网页：www.creslab.com
团队简介：
团队成立于2017年7月，依托四川省“天府峨眉计划”及四川师范大学引进人才项目，建设了包括一系列遗传转化、基因组学实验仪器，智能人工气候室及大型服务器的的高效研究平台。团队主要以西南特色作物马铃薯及青稞为研究对象，以多组学为研究手段，从事重要功能基因克隆及其调控元件鉴定，揭示作物生长发育及非生物胁迫的分子应答机制及表观调控模式，着力实现以顺式调控元件为靶点的精准分子设计育种。团队成员现包括教授2人，助理研究员3人，科研助理2人，其中包括四川省峨眉计划入选者2人，四川省特聘专家2人，四川省学术技术带头人后备人选1人，四川师范大学狮山学者-杰出青年学者1人，具有海外留学经历3人。
研究方向（西南特色作物）：
· 马铃薯、青稞全基因组顺式调控元件功能及调控机制
· 马铃薯结薯光温调控机制及遗传改良
· 马铃薯淀粉代谢调控机制及遗传改良
· 青稞抗倒伏分子机制及改良
主持项目（2017-至今）：
· 国家重点研发计划项目子课题1项；
· 国家自然科学基金面上/青年项目共4项；
· 四川省科技厅国际合作（重点）项目3项；
· 四川省重点研发项目“十四五育种攻关”子课题1项；
· 国家重点实验室合作项目3项；
· 国家教育部重点项目合作项目2项；
· 四川省重点实验室合作项目2项；
· 四川省科技创新（苗子工程）培育项目3项；
代表性论文（一作/通讯）：
Wang, H., C. Yin, G. Zhang, M. Yang, B. Zhu, J. Jiang and Z. Zeng (2024) Cold-induced deposition of bivalent H3K4me3-H3K27me3 modification and nucleosome depletion in Arabidopsis. Plant J, https://doi.org/10.1111/tpj.16624.
Zhu, X., A. Chen, N. M. Butler, Z. Zeng, H. Xin, L. Wang, Z. Lv, D. Eshel, D. S. Douches and J. Jiang (2024) Molecular dissection of an intronic enhancer governing cold-induced expression of the vacuolar invertase gene in potato. Plant Cell, koae050
Guo, H., Zhang, G., Zhou, M., Wan, M., Zhu, B., Yang, Z., Zeng, D. and Zeng, Z. (2023a) Whole genome doubling-induced the enrichment of H3K27me3 in genes carrying specific TEs in Aegilops tauschii. Front Genet, 14, 1241201.
Guo, H., Zhou, M., Zhang, G., He, L., Yan, C., Wan, M., Hu, J., He, W., Zeng, D., Zhu, B. and Zeng, Z. (2023b) Development of homozygous tetraploid potato and whole genome doubling-induced the enrichment of H3K27ac and potentially enhanced resistance to cold-induced sweetening in tubers. Hortic Res, 10, uhad017.
Jing, S., Jiang, P., Sun, X., Yu, L., Wang, E., Qin, J., Zhang, F., Prat, S. and Song, B. (2023) Long-distance control of potato storage organ formation by SELF PRUNING 3D and FLOWERING LOCUS T-like 1. Plant Commun, 4, 100547.
唐珂, 严彩虹, 朱博，曾子贤 (2023) 马铃薯淀粉代谢相关基因及其顺式调控元件的分子研究进展. 农业生物技术学报, 31, 833-843.
Wang, J., Li, X., Dong, Q., Li, C., Li, J., Li, N., Ding, B., Wang, X., Yu, Y., Wang, T., Zhang, Z., Yu, Y., Lang, M., Zeng, Z., Liu, B. and Gong, L. (2022) Chromatin architectural alterations due to null mutation of a major CG methylase in rice. J Integr Plant Biol, 64, 2396-2410.
Begum, S., Jing, S., Yu, L., Sun, X., Wang, E., Abu Kawochar, M., Qin, J., Liu, J. and Song, B. (2022) Modulation of JA signalling reveals the influence of StJAZ1-like on tuber initiation and tuber bulking in potato. Plant J, 109, 952-964.
Jing, S., Begum, S., Yu, L., Kawochar, M.A., Wang, E., Chen, Y., Zhao, J. and Song, B. (2022a) StJAZ1-like mediated root architecture plays critical roles in drought susceptibility in potato. Environmental and Experimental Botany, 202, 105008.
Jing, S., Sun, X., Yu, L., Wang, E., Cheng, Z., Liu, H., Jiang, P., Qin, J., Begum, S. and Song, B. (2022b) Transcription factor StABI5-like 1 binding to the FLOWERING LOCUS T homologs promotes early maturity in potato. Plant Physiol, 189, 1677-1693.
Wu, P., Xu, C., Chen, H., Yang, J., Zhang, X. and Zhou, S. (2021) NOVOWrap: An automated solution for plastid genome assembly and structure standardization. Mol Ecol Resour, 21, 2177-2186.
Zeng, D., Guan, J., Luo, J., Zhao, L., Li, Y., Chen, W., Zhang, L., Ning, S., Yuan, Z., Li, A., Zheng, Y., Mao, L., Liu, D. and Hao, M. (2020) A transcriptomic view of the ability of nascent hexaploid wheat to tolerate aneuploidy. BMC Plant Biol, 20, 97.
Zeng, Z.X., Zhang, W.L., Marand, A.P., Zhu, B., Buell, C.R. and Jiang, J.M. (2019) Cold stress induces enhanced chromatin accessibility and bivalent histone modifications H3K4me3 and H3K27me3 of active genes in potato. Genome Biol, 20.
Zeng, Z.X. and Jiang, J.M. (2016) Isolation and Proteomics Analysis of Barley Centromeric Chromatin Using PICh. J Proteome Res, 15, 1875-1882.
Zeng, D., Luo, J., Li, Z., Chen, G., Zhang, L., Ning, S., Yuan, Z., Zheng, Y., Hao, M. and Liu, D. (2016) High transferability of homoeolog-specific markers between bread wheat and newly synthesized hexaploid wheat lines. PloS one, 11, e0162847.
Zhu, B., Zhang, W., Zhang, T., Liu, B. and Jiang, J. (2015) Genome-Wide Prediction and Validation of Intergenic Enhancers in Arabidopsis Using Open Chromatin Signatures. Plant Cell, 27, 2415-2426.
Zhang, H., Zhu, B., Qi, B., Gou, X., Dong, Y., Xu, C., Zhang, B., Huang, W., Liu, C., Wang, X., Yang, C., Zhou, H., Kashkush, K., Feldman, M., Wendel, J.F. and Liu, B. (2014) Evolution of the BBAA component of bread wheat during its history at the allohexaploid level. Plant Cell, 26, 2761-2776.
Zeng, D.-Y., Hao, M., Luo, J.-T., Zhang, L.-Q., Yuan, Z.-W., Ning, S.-Z., Zheng, Y.-L. and Liu, D.-C. (2014) Amphitelic orientation of centromeres at metaphase I is an important feature for univalent-dependent meiotic nonreduction. Journal of genetics, 93, 531-534.
Zeng, Z.X., Zhang, T., Li, G.R., Liu, C. and Yang, Z.J. (2012) Phenotypic and Epigenetic Changes Occurred during the Autopolyploidization of Aegilops tauschii. Cereal Res Commun, 40, 476-485.
Zhao, N., Zhu, B., Li, M., Wang, L., Xu, L., Zhang, H., Zheng, S., Qi, B., Han, F. and Liu, B. (2011) Extensive and heritable epigenetic remodeling and genetic stability accompany allohexaploidization of wheat. Genetics, 188, 499-510.
Zeng, Z.X., Yang, Z.J., Liu, C., Hu, L.J. and Ren, Z.L. (2009) Isolation, mapping and application of a repetitive DNA sequence in wheat (Triticum aestivum) A and B genomes. Chinese Journal of Agricultural Biotechnology, 6, 211-226.
本科生项目及获奖（2017-至今）：
· 大学生创新创业项目国家级/省级重点项目4项
· 全国大学生生命科学竞赛一等奖1项、二等奖1项、三等奖2项
· 四川省“生命之星“科技竞赛一等奖2项、
【编辑：朱博】
